Clinical Observations with New Amoebicidal Drugs

P-glycolylaminophenylarsonic acid (Viasept) was first shown in 1938 to possess curative activity in experimental amcebiasis of cats (cf. Wagner, 1951). Subsequent clinical trials were encouraging (particularly in cyst carriers) and it was at that time also stated that the drug would be suitable for prophylactic treatment owing to lack of toxic effects (Hauer, 1943)? These early reports were followed by a lar?e number of clinical investigations (Berberian, 1948, Sodeman and Beaer, 1952, Wilmet et 1951. Hcekenga, 1952), some of them substantiating the previously obtained results, others showing less convincing results. Particularly interesting is the observation of Vegas (1953) from a recent extensive study with this coinpound that about 50 per cent of the treated patients continued to pass cysts in their stools although the trophozoites disappeared in